Proteomics is the analysis of the entire protein complement of a cell, tissue or organism under a specific, defined set of conditions. It has been enabled by the accumulation of both DNA and protein sequence databases. A proteome is a set of proteins produced in an organism, system or biological context. Proteome differs from cell to cell and changes over time. Proteomics can provide significant biological information for many biological problems such as: which proteins interact with a particular protein of interest, which proteins are localised to a subcellular compartment, which proteins are involved in a biological process (for example, circadian rhythm). It is used to investigate: when and where the proteins are expressed, rates of protein production, degradation and steady-state abundance, how proteins are modified (for example, post-translational modifications (PTMs) such as phosphorylation), the movement of proteins between subcellular compartments, the involvement of proteins in metabolic pathways and how proteins interact with one another.

Shivangi Ojha

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