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Nucleic Acids Composition, Structure, Metabolism Disorders

Presentations | English

MicroRNAs (miRNAs) and small interfering RNAs (siRNAs), which can induce endonuclease (argonaut protein; Ago2) cleavage or decapping, are involved in nucleic acid metabolism. The synthesis and polymerization of nucleotides into macromolecular structures like DNA and RNA, as well as their subsequent modification, catabolism, and excretion, are all part of nucleic acid metabolism. In addition to the relatively easy nucleic acid catabolism pathways, metabolomics investigations must also include salvage pathways, which allow partial catabolism products to be rediverted back into an anabolic pathway and reincorporated into new macromolecular structures. Clearly, since DNA and RNA molecules are polynucleotides, composed of an invariant sugar-phosphate backbone, it comes as no surprise that many of the enzymes involved in their metabolism require Mg2+ ions. We do not consider here how this very large number of enzymes achieve their structure or sequence specificity, although the sensitivity of ligand geometry and electrostatic environment of Mg2+ ions is proposed to greatly enhance substrate recognition and catalytic specificity (for a review, see Yang, Lee, & Nowotny, 2006), but rather consider the role of the metal ions.

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Nucleic Acids Composition, Structure, Metabolism Disorders

Presentations | English